Fat attack

日期:2019-03-07 06:07:03 作者:饶驹 阅读:

A TYPE of fat in the membrane of a bacterium may be fatal for cystic fibrosis patients. The bug, Pseudomonas aeruginosa, often infects the lungs of CF infants soon after birth. “What ultimately kills CF kids is that infection and the inflammation it causes,” says Samuel Miller of the University of Washington in Seattle. His team has shown that P. aeruginosa alters a fat in its outer membrane, called lipid A, by attaching sugar and fatty acid chains. This altered fat protects P. aeruginosa against the body’s defences and promotes inflammatory responses, suggesting that the bacterium plays an important role in the progression of the disease (Science, vol 286,